The pregnane x receptor

Author: wlyy

August undefined, 2024

WebbPregnane X receptor (NR1I2) is a broad-specificity sensor playing a critical role in the regulation of phase I oxidative enzymes, phase II conjugating enzymes, and phase III … Webb关键词：孕烷X 受体；CYP3A4；药物代谢中图分类号：R969.1 文献标志码：A 文章编号：1007-7693(2013)12-1357-03 Role of Pregnane X Receptor(PXR) in Drug Metabolism …

Pregnane X Receptor: Understanding Its Function and Activity at …

WebbMicroRNA-140-3p enhances the sensitivity of hepatocellular carcinoma cells to sorafenib by targeting pregnenolone X receptor Jiaqi Li,1,2 Jing Zhao,2 Huan Wang,2 Xiaohan Li,2 … WebbFarnesoid X receptor (FXR), a member of the nuclear receptor superfamily that is mainly expressed in enterohepatic tissues, has been discovered as a crucial regulator for balancing liver inflammatory processes and metabolism [ 5, 6, 7] and thus has become a pharmacological target for liver disorders. dhs communities of interest

Characterization of human pregnane X receptor activators …

http://www.paper.edu.cn/scholar/showpdf/MUT2QNyIMTD0YxeQh Webb1 aug. 2004 · P-Glycoprotein (P-gp) and cytochrome P450 3A4 (CYP3A4) constitute a physiologic barrier in the intestine for many of the same substrates. Their expression … WebbPregnane X receptor Function . PXR belongs to the nuclear receptor superfamily, members of which are transcription factors characterized by... Ligands . PXR is activated by a … dhs commonwealth of pa

Evolution of the Pregnane X Receptor: Adaptation to Cross …

The nuclear pregnane X receptor: a key regulator of xenobiotic ...

Webb10 sep. 2024 · Pregnane X Receptor (PXR) is a ligand-activated transcription factor which binds many structurally different molecules. The receptor is able to regulate the … WebbThe pregnane X receptor (PXR) is a member of the nuclear receptor family of ligand-regulated transcription factors. Like many former orphan nuclear receptors, it contains … cincinnati bengals straw hatWebbPXR is remarkably divergent between species, with the rabbit, rat, and human receptors sharing only approximately 80% amino acid identity in their ligand-binding domains. … cincinnati bengals state

"Webb19 jan. 2024 · The pregnane X receptor (PXR) is implicated in fatty liver, vitamin D homeostasis, bile acids homeostasis, steroid hormones homeostasis and inflammatory … " - The pregnane x receptor

The pregnane x receptor

Regulation of mRNA Expression of Xenobiotic Transporters by the ...

WebbThe nuclear pregnane X receptor (PXR; NR1I2) is an important component of the body's adaptive defense mechanism against toxic substances including foreign chemicals … Webb18 apr. 2016 · The nuclear xenobiotic pregnane X receptor (PXR) is well established as a transcriptional regulator of phase I and phase II drug-metabolizing enzymes and drug …

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WebbAbstract Efavirenz is metabolized by CYP2B6, an inducible enzyme whose expression is regulated by the constitutive androstane receptor and pregnane X receptor nuclear … WebbWe studied in mice and human adenocarcinoma-derived Caco-2 cells the impact of low calcium on markers of inflammation (cyclooxygenase-2; COX-2), of detoxification (pregnane and xenobiotic receptor (PXR)/steroid and xenobiotic receptor (SXR), cytochrome P450 steroid-inducible 3a11 (CYP3A11)), and on expression of the vitamin D …

WebbThe pregnane X receptor (PXR) regulates expression of proteins responsible for all three phases required for the detoxification mechanism, which include CYP450 enzymes, … Webb18 mars 2009 · Pregnane X receptor (PXR) is an important component of the body's adaptive defense system responsible for the elimination of various toxic xenobiotics. …

Webb29 sep. 2014 · Pregnane X receptor (PXR) is an important member of the nuclear receptor superfamily that copes with various endobiotic and xenobiotic stimuli, such as carcinogens by regulating an array of environmental response genes. Low PXR expression has been shown to promote tumor initiation and metastasis. The aim of the current study was to … Webb2006 Orphan nuclear receptor pregnane X receptor sen-sitizes oxidative stress responses in transgenic mice and cancerous cells. Mol Endocrinol 20:279–290 24. Curnow KM, …

WebbPregnane X receptor is a ligand-activated nuclear receptor (NR) that mainly controls inducible expression of xenobiotics handling genes including biotransformation …

Webb1 juli 2024 · The pregnane X receptor (PXR) is a ligand-activated nuclear receptor that acts as a xenobiotic sensor, responding to compounds of foreign origin, including … dhs commonwealth seniors health cardWebbThe pregnane X receptor (PXR) is a xenobiotic nuclear receptor that is also sensitive to bile acids as ligands.10,11 A study in this issue of Arteriosclerosis, Thrombosis, and … dhs community health worker certificationWebb1 juli 2005 · THE PREGNANE X RECEPTOR (PXR; NR1I2), a member of the nuclear hormone receptor (NR) superfamily, is a key regulator of bile salt, steroid hormone, and xenobiotic … cincinnati bengals stickers for helmetsWebbThe pregnane X receptor (PXR) is a promiscuous nuclear receptor that has evolved to protect the body from toxic chemicals. PXR is activated by a structurally diverse … dhs community testingWebb1 nov. 2006 · The pregnane X receptor (PXR) is a major chemical sensor known to activate the expression of CYP3A/Cyp3a in humans and rodents. The purpose of this study is to … dhs community paramedicWebb15 okt. 2024 · Pregnane X receptor (PXR, NR1I2) is a member of the ligand-activated nuclear receptor superfamily. This receptor is promiscuous in its activation profile and is … cincinnati bengals stocking capWebb1 dec. 1999 · Two of these sites, FP3 (bases -7738 to -7715) and FP4 (bases -7698 to -7682), overlapped binding motifs for the orphan human pregnane X receptor (hPXR). … cincinnati bengals stuffed tiger