Peroxisome proliferator-activated receptor alpha (PPAR-α), also known as NR1C1 (nuclear receptor subfamily 1, group C, member 1), is a nuclear receptor protein functioning as a transcription factor that in humans is encoded by the PPARA gene. Together with peroxisome proliferator-activated receptor delta … See more PPAR-α is primarily activated through ligand binding. Endogenous ligands include fatty acids such as arachidonic acid as well as other polyunsaturated fatty acids and various fatty acid-derived compounds such as … See more Expression of PPAR-α is highest in tissues that oxidize fatty acids at a rapid rate. In rodents, highest mRNA expression levels of PPAR-alpha are found in liver and brown adipose tissue, followed by heart and kidney. Lower PPAR-alpha expression levels are found in … See more PPAR-α is the pharmaceutical target of fibrates, a class of drugs used in the treatment of dyslipidemia. Fibrates effectively lower serum triglycerides and raises serum HDL-cholesterol levels. Although clinical benefits of fibrate treatment have been … See more PPAR-α has been shown to interact with: • AIP, • EP300 • HSP90AA1, • NCOA1, and • NCOR1. See more PPAR-α is a transcription factor regulated by free fatty acids, and is a major regulator of lipid metabolism in the liver. PPAR-alpha is activated under conditions of energy deprivation … See more Studies using mice lacking functional PPAR-alpha indicate that PPAR-α is essential for induction of peroxisome proliferation by a diverse set of synthetic compounds referred to as peroxisome proliferators. Mice lacking PPAR-alpha also have an … See more PPAR-α governs biological processes by altering the expression of a large number of target genes. Accordingly, the functional role of PPAR-alpha is directly related to the … See more WebMar 21, 2024 · Peroxisome proliferator-activated receptors (PPARs) are essential nuclear hormone receptors regulating metabolic processes, and they participate in the initiation and progression processes of tumors. Gastrointestinal (GI) cancer is a prevalent malignancy worldwide that originates from the tissues of the gastrointestinal tract and is ...

Multiple Interactions between Peroxisome Proliferators-Activated ...

WebOct 13, 2003 · Peroxisome proliferator–activated receptor-α (PPAR-α) is a ligand-activated transcription factor belonging to the nuclear receptor superfamily. PPAR-α increases gene transcription by binding as a heterodimer with the retinoid X receptor (RXR) to PPAR response elements in the promoter regions of the target gene. WebFeb 9, 2012 · Peroxisome proliferator-activated receptors (PPARs) are ligand-activated transcription factors. The three PPAR isoforms, PPARα, PPARβ/δ (also known as PPARβ or PPARδ) and PPARγ, are found in... froehling \u0026 robertson inc richmond va

Peroxisome proliferator-activated receptor-α (PPARα) regulates …

WebPeroxisome-proliferator activator receptors (PPARs) form a family of nuclear hormone-activated receptors and transcription factors that regulates the function and expression … WebPeroxisome proliferator-activated receptor-α (PPARα) is a nuclear hormone receptor which regulates the oxidation and transport of fatty acids. Upon activation it binds as a … WebApr 22, 2016 · After injury, the protein and gene expression of carnitine palmitoyltransferase 1A, fatty acid transport protein 1, and peroxisome proliferator-activated receptor-α decreased significantly in liver tissue. In contrast, after treatment with fish oil, the expression levels of these targets increased compared with those in the saline group. ... froehling \u0026 robertson charlotte nc