WebGlucose-Dependent Insulinotropic Polypeptide or Gastric Inhibitory Peptide. GIP is an incretin that is secreted in the proximal small intestine in the presence of nutrients in the gut. GIP was first named gastric inhibitory peptide because it was thought to decrease gastric acid secretion; however, later studies demonstrated that its main ... WebGIP is derived from a 153-amino acid proprotein encoded by the GIP gene and circulates as a biologically active 42-amino acid peptide. It is synthesized by K cells, which are found in the mucosa of the duodenum and the jejunum of the gastrointestinal tract. [8] Like all endocrine hormones, it is transported by blood. [citation needed]
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Role of GIP Receptor in the CNS for the Pathogenesis of Obesity
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