Chitosan osteoarthritis gene delivery
WebFeb 23, 2024 · Keywords: Osteoarthritis, Gene therapy, Chitosan, Hyaluronic acid, Chondroitin sulfate, Growth and differentiation factor-5 (GDF-5) plasmid. 1. ... HA and CHS enabled the non-viral vector itself to have some therapeutic effects on OA, making it much more suitable for delivery of gene therapy treatments for OA. WebApr 12, 2024 · Chitosan is a naturally occurring polysaccharide that is derived from chitin, a major component of the exoskeletons of crustaceans such as shrimp, crab, and lobster. It has been gaining attention in the field of biotechnology and biomedicine due to its unique properties and potential applications. Chitosan is a linear polysaccharide that consists of …
Chitosan osteoarthritis gene delivery
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WebChitosan can act itself as a precursor or carrier for medical applications such as drug delivery, gene delivery, and wound healing. With the advancement in science technology, it was clearly observed that the amine groups present in chitosan are responsible for various properties such as antimicrobial activity, stability in a wide pH range ... WebMar 3, 2006 · All these studies point to the versatility and promise of chitosan as a gene carrier, although only limited in vivo efficacy has been demonstrated. Due to the complex …
WebIntroduction. Cartilage injury, a common clinical problem, can be caused by trauma, 1 osteoarthritis, 2 rheumatoid arthritis, 3 and exfoliative chondritis. 4 Articular cartilage is … Webdesigned to develop and evaluate the chitosan-graft-polyethylenimine (CP)/DNA nanoparticles as novel non-viral gene vectors for gene therapy of osteoarthritis.
WebDec 1, 2024 · Chitosan, a biopolymer of natural origin, has been explored for its variety of applications in biomedical research, medical diagnostic aids and material science. It is the second most abundant natural biopolymer after cellulose, and considered as an excellent excipient because of its non-toxic, stable, biodegradable properties. WebJan 1, 2024 · The chitosan-based gene delivery system has several characteristics such as insignificant cellular toxicity, high gene delivery ability, targeting of particular cells, …
WebFeb 15, 2024 · 1. Introduction. Osteoarthritis (OA) is a progressive and degenerative joint disease that causes articular cartilage damage, synovial inflammation, and subchondral bone remodeling [1].World Health Organization (WHO) estimates that 9.6% of men and 18.0% of women aged over 60 years have symptomatic OA [2].OA affects life quality of …
WebOct 16, 2024 · 2.2. CS-Based Modifications for Targeted Drug Delivery. When a drug enters the human body, various obstacles prevent it from reaching the disease site to elicit a specific therapeutic effect [].More importantly, drug often impart severe toxic side effects [].The current most effective strategy for solving the issues above mentioned is targeted … order birth certificate nswWebNov 28, 2011 · Gene therapy, which treats the causes of osteoarthritis by targeting specific pathological mechanisms, is attracting much attention as a promising new treatment … order birth certificate online birminghamWebJan 2, 2014 · The development of safe and efficient gene carriers is the key to the clinical success of gene therapy. The present study was designed to develop and evaluate the chitosan-graft-polyethylenimine (CP)/DNA nanoparticles as novel non-viral gene vectors for gene therapy of osteoarthritis. order birth certificate online coventryWebJan 2, 2014 · The present study was designed to develop and evaluate the chitosan-graft-polyethylenimine (CP)/DNA nanoparticles as novel non-viral gene vectors for gene … order birth certificate online albertaWebJun 1, 2024 · Chitosan is a natural polymer with inherent antibacterial activity and a hemostasis and wound healing acceleration capability, so it has been used in drug … irby homes floridaWebApr 11, 2024 · 1.3.1.Advantageous properties of chitosan as a biomaterial. Chitosan has a structure similar to that of glycine aminoglycan, which is widely distributed in connective tissue, giving chitosan good biocompatibility (Malafaya et al., 2007).Chitosan-based biomaterials do not cause cytotoxicity or genotoxicity and promote cell proliferation and … order birth certificate ohio onlineWebJan 1, 2024 · Thermoresponsive DDS, chitosan-modified MoS 2 (molybdenum disulfide), was shown to release a small molecule drug, dexamethasone (Dex) ... is most commonly employed osteoarthritis therapeutic for gene delivery; currently there are two ongoing trials for intra-articular delivery using an AAV (NCT02790723) and an HDAV … irby house whaplode