Chic2 gene

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August undefined, 2024

WebNov 12, 2015 · The FIP1L1-PDGFRA rearrangement is caused by a cryptic deletion of 800kb on chromosome 4q12 and contains the CHIC2 gene [15], the incidence of this entity as part of the HES is not known, those with fusion protein rearrangements are very rare, estimated to be <1/100,000 persons with HES. WebMar 29, 2024 · Go to Variation Viewer for CHIC2 variants; Summary. This gene encodes a member of the CHIC family of proteins. The encoded protein contains a cysteine-rich …

AceView: Gene:CHIC2, a comprehensive annotation of human, …

WebCHIC2 deletion, a surrogate for FIP1L1/PDGFRA fusion, occurs in systemic mastocytosis with eosinophilia and predicts response to imatinib mesylate therapy. Blood … WebThis one megabase submicroscopic, intrachromosomal deletion results in loss of the CHIC2 gene region with subsequent fusion of neighboring genes FIP1L1 and PDGFRA. In … pottery barn bowling green ky

CHIC2 deletion, a surrogate for FIP1L1-PDGFRA fusion, …

WebConditions and phenotypes associated with each gene as reported by OMIM, GeneReviews and Gene. Select item 26511: CHIC2. Tests; Acute myeloid leukemia; Results: 1 to 1 of … WebThe closest mouse gene, according to BlastP, is the AceView gene Chic2(e=7 10-73). The closest C.elegans gene, according to BlastP, is the AceView/WormGene 3B256(e=2 10-30) RNA_seq discoveries. Expression/conservation in primates tissues evaluated by cross-mapping to human. WebClinical Significance. FISH, HES/Leukemia, 4q12 Rearrangement (FIP1L1-PDGFRA) - FIP1L1-PDGFRa fusion (rearrangement of 4q12; interstitial deletion of CHIC2 region) is observed in diverse eosinophilia-associated hematologic disorders. The cases with FIP1L1-PDGFRa fusion show an excellent response to the tyrosine kinase inhibitor imatinib ... touch ups shoes benjamin walk

CHIC2 protein expression summary - The Human Protein Atlas

Web胎牛血清（杂交瘤细胞专用） sp2/0 小鼠骨髓瘤细胞. 佐剂乳化器 WebFeb 9, 2024 · FIP1L1-PDGFRA is generated from a submicroscopic 800-kb interstitial deletion on chromosome 4, del (4) (q12q12). 23, 24 The deleted segment contains the CHIC2 gene, which is the basis for the commonly used FISH test used to diagnose FIP1L1-PDGFRA -positive disease. 25 However, because of the rare possibility of complex … pottery barn box cushion slip coversWebNotably, cases of acute myeloid leukemia with a CHIC2-ETV6 fusion gene have been reported indicating a possible role of CHIC2 in cancer [14]. However, its function remains largely unknown. ... touchup store.com

"WebDescription: Homo sapiens cysteine-rich hydrophobic domain 2 (CHIC2), mRNA. RefSeq Summary (NM_012110): This gene encodes a member of the CHIC family of proteins. … " - Chic2 gene

Chic2 gene

WikiGenes - CHIC2 - cysteine-rich hydrophobic domain 2

WebFunctional Associations. CHIC2 has 5,675 functional associations with biological entities spanning 8 categories (molecular profile, organism, chemical, functional term, phrase or reference, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA) extracted from 67 datasets. WebJan 1, 2024 · The t(4;12)(q12;p13) has been rarely reported in both myeloid/lymphoid neoplasms with eosinophilia (ETV6/PDGFRA gene fusion) and acute myeloid leukemia (AML) (ETV6/CHIC2 gene fusion).The ability to accurately characterize t(4;12) is critical as myeloid neoplasms with PDGFRA rearrangements may be amenable to tyrosine kinase …

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WebPanel Description. Sequence variants and/or copy number variants (deletions/duplications) within the CHIC2 gene will be detected with >99% sensitivity. Variants classified as …

WebARNT, TTL, BA22A, FCHO2, MDS2 ve CHIC2 ile ETV6 gen füzyonlarının kimerik protein ürünleri de benzer şekilde ETV6 proteininin transkripsiyon faktörü aktivitesinden yoksundur. ETV6 ve homeobox genleri (yani CDX2, PAX5 ve MNX1) arasındaki gen füzyonları , ETV6'lar ve/veya CDX2'ler, PAX5'ler veya MNX1s transkripsiyon faktörü ... http://www.informatics.jax.org/marker/MGI:1921527

WebFeb 1, 2002 · Gene name CHIC2 (cystein-rich hydrophobic domain 2) Location 4q12 Note CHIC2 is involved in the AML cases; there is no data concerning ALL cases Protein description contains a transmembrane domain; member of a family of proteins with function in exocytosis. Gene name ETV6 (ets variant 6) Location 12p13.2 Dna rna description WebTitle: SLC1A2 Gene Rearrangement Definition: A molecular abnormality indicating rearrangement of the SLC1A2 gene. Semantic Type: Cell or Molecular Dysfunction Semantic ID: T049 Concept ID: C5670928 ID: 1812369 9. Title: CHIC2 Gene Rearrangement Definition: A molecular abnormality indicating rearrangement of the …

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WebFeb 1, 2002 · N term CHIC2 with the first 110 amino acids (exons 1 to 3) fused to the441 C term amino acids (exons 2 to 8) of ETV6. Bibliography. Pubmed ID Last Year Title Authors; 10477709: 1999: Fusion of a novel gene, BTL, to ETV6 in acute myeloid leukemias with a t(4;12)(q11-q12;p13). Cools J et al: 11257495: 2001: A new family of small, palmitoylated ... touch up stuffWebSep 1, 2024 · Gene: CHIC2; cysteine rich hydrophobic domain 2: Aliases: BTL : Location: 4q12: Summary: This gene encodes a member of the CHIC family of proteins. The … touch up stainWebCHIC2 deletion was observed in bone marrow cells for 3 of 5 patients with SMCD associated with eosinophilia [1]. We recently cloned the CHIC2 gene (previously BTL) by virtue of its involvement in a chromosomal translocation t (4;12) (q11;p13) occurring in acute myeloid leukemias [2]. pottery barn bowlsWebFISH analysis using an XL FIP1L1/CHIC2/PDGFRA probe (Metasystems, Altlus-sheim, Germany) showed 2 orange/green fusions and 1 green signal in 82% of cells, indicating a translocation involving a breakpoint at 4q12 (Fig. 2C ). An LSI ETV6/RUNX1 ES dual-color translocation probe (Abbott Molecular) showed 3 green signals, suggesting an ETV6 … pottery barn boxesWebCHIC2 deletion was observed in bone marrow cells for 3 of 5 patients with SMCD associated with eosinophilia [1]. We recently cloned the CHIC2 gene (previously BTL) by … touch up spray gun reviewWebMar 21, 2024 · GeneCards Summary for CHIC2 Gene. CHIC2 (Cysteine Rich Hydrophobic Domain 2) is a Protein Coding gene. Diseases associated with CHIC2 include Leukemia, Acute Myeloid and Leukemia . An important paralog of this gene is CHIC1. touch up stain pensWebA chromosomal aberration involving CHIC2 is found in a form of acute myeloid leukemia (AML). Translocation t(4;12)(q12;p13) with ETV6 1 publication. ... Gene name Length; D6RDW7: D6RDW7_HUMAN: CHIC2: 146: H0Y8H1: H0Y8H1_HUMAN: CHIC2: 137: Keywords. Coding sequence diversity. #Chromosomal rearrangement; Technical term. … touch up store